You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air

https://tysonzxpg006.solsticebrief.com/posts/common-entry-points-rodents-use-to-get-under-san-diego-homes

You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air and raise the risk of exposure to rodent-borne diseases.